ChloroquineV1, Main, Exploration, bibRecord, 003559

Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria

Identifieur interne : 003559 ( Main/Exploration ); précédent : 003558; suivant : 003560

Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria

Auteurs : Wijnand M. C. Eling [Pays-Bas] ; Christoph R. Jerusalem [Pays-Bas] ; Ute Heinen-Borries [Pays-Bas]

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1984.

RBID : ISTEX:35CC25A1F489D19B92C287D9060D540A33641E6F

English descriptors

Teeft :
- Basal, Basal lamina, Berghei, Cell migration, Colloidal thorium dioxide, Early changes, Electron microscopy, Eling, Endocardial, Endocardial endothelium, Endocardium, Endomyocardial, Endomyocardial fibrosis, Endothelial, Endothelial barrier, Endothelial cell, Endothelial cells, Endothelium, Erythrocyte, Free surface, Granulocyte, Lamina, Large amounts, Lesion, Macrophage, Malarial pigment, Mural thrombi, Murine malaria, Myocardial cell, Parasite, Parasitized, Parasitized cells, Parasitized erythrocytes, Right half, Subendothelial, Subendothelial space, Thorium, Thrombus, Thrombus formation, Tracer.

Abstract

C57B1/Rij mice developed progressive endocardial oedema and extensive endocardial thrombosis with a predilection for the right half of the heart in the course of a lethal Plasmodium berghei infection. Chemotherapy of an ongoing infection resulted in fibrosis of affected areas. Despite a close correlation between development of lesions and parasitaemia, parasitized erythrocytes were not usually present in the affected areas. Macrophages might play, however, an important role in the pathogenesis of the lesions. Early changes included sticking of macrophages to the endocardial endothelium, migration to subendothelial areas associated with leakage, and oedema. Subsequently, subendothelial infiltrates of lymphocytes, neutrophilic granulocytes, macrophages and fibroblasts were found. Moreover, endothelial lesions, sometimes associated with cell migration, were found to be plugged by microthrombi. Mural thrombi grew out eventually until death of the host or until chemotherapy cleared the infection.

Url:

DOI: 10.1016/0035-9203(84)90169-X

Affiliations:

Pays-Bas

Le document en format XML

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<term>Colloidal thorium dioxide</term>
<term>Early changes</term>
<term>Electron microscopy</term>
<term>Eling</term>
<term>Endocardial</term>
<term>Endocardial endothelium</term>
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<term>Endothelial cells</term>
<term>Endothelium</term>
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<term>Free surface</term>
<term>Granulocyte</term>
<term>Lamina</term>
<term>Large amounts</term>
<term>Lesion</term>
<term>Macrophage</term>
<term>Malarial pigment</term>
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<term>Murine malaria</term>
<term>Myocardial cell</term>
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<term>Parasitized erythrocytes</term>
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<term>Subendothelial space</term>
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<front><div type="abstract">C57B1/Rij mice developed progressive endocardial oedema and extensive endocardial thrombosis with a predilection for the right half of the heart in the course of a lethal Plasmodium berghei infection. Chemotherapy of an ongoing infection resulted in fibrosis of affected areas. Despite a close correlation between development of lesions and parasitaemia, parasitized erythrocytes were not usually present in the affected areas. Macrophages might play, however, an important role in the pathogenesis of the lesions. Early changes included sticking of macrophages to the endocardial endothelium, migration to subendothelial areas associated with leakage, and oedema. Subsequently, subendothelial infiltrates of lymphocytes, neutrophilic granulocytes, macrophages and fibroblasts were found. Moreover, endothelial lesions, sometimes associated with cell migration, were found to be plugged by microthrombi. Mural thrombi grew out eventually until death of the host or until chemotherapy cleared the infection.</div>
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Serveur d'exploration Chloroquine

Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria

Role of macrophages in the pathogenesis of endomyocardial fibrosis in murine malaria

Source :

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

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